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Related Experiment Video

Updated: Jun 19, 2026

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection

Published on: August 23, 2022

Emerging infections in burns.

Ludwik K Branski¹, Ahmed Al-Mousawi, Haidy Rivero

¹Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA.

Surgical Infections

|October 9, 2009

Summary

Colistin effectively treats multidrug-resistant gram-negative infections in severe burn patients, though mortality remains higher in this group. Careful antibiotic use and infection control are crucial for combating resistant pathogens.

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Area of Science:

Infectious Diseases
Critical Care Medicine
Burn Management

Background:

Severe burns (>40% TBSA) increase infection risk from multidrug-resistant pathogens.
Resistant bacteria like Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter spp. elevate burn patient morbidity and mortality.
Multi-drug-resistant Staphylococcus aureus is a primary cause of gram-positive burn wound infections globally.

Purpose of the Study:

To evaluate the efficacy and safety of colistin in treating severe burn patients with multidrug-resistant gram-negative infections.
To compare outcomes between patients treated with colistin and standard antibiotic regimens.

Main Methods:

Retrospective review of 398 severely burned patients (burns >40% TBSA) from 2000-2006.
Control group (n=280): received vancomycin and piperacillin/tazobactam.
Treatment group (n=118): received vancomycin and colistin for multidrug-resistant gram-negative infections.

Main Results:

Colistin demonstrated high efficacy against multiresistant Pseudomonas and Acinetobacter burn infections.
Colistin-treated patients had larger burns and higher mortality (p < 0.05) but no increased neurotoxicity, hepatic toxicity, or nephrotoxicity.
Candida, Aspergillus, and Fusarium spp. are key fungal pathogens; Amphotericin B and voriconazole are primary antifungals.

Conclusions:

Advances in burn care reduce morbidity and mortality, but resistant organisms pose ongoing challenges.
Colistin is a vital option for multidrug-resistant gram-negative infections, while vancomycin and clindamycin are key for MRSA.
Combating resistant pathogens requires new agents, judicious antibiotic use, and enhanced infection control protocols.