Bupropion for attention deficit hyperactivity and comorbid disorders.
W Burleson Daviss1, Raymond J Pan, James M Perel
1Department of Psychiatry, University of Pittsburgh Medical Center, 3811 0'Hara Drive, Pittsburgh, PA 15213, USA. davisswb@msx.upmc.edu
Expert Review of Neurotherapeutics
|October 9, 2009
Summary
Bupropion, an antidepressant affecting norepinephrine and dopamine, shows effectiveness for attention deficit hyperactivity disorder (ADHD) across all ages. It is generally well-tolerated and may treat co-occurring conditions like depression and anxiety.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Attention deficit hyperactivity disorder (ADHD) is linked to catecholamine system dysregulation.
- Bupropion, an antidepressant with noradrenergic and dopaminergic activity, has been investigated for ADHD treatment.
- Existing research supports bupropion's efficacy in managing ADHD symptoms throughout life.
Purpose of the Study:
- To review the efficacy of bupropion in treating attention deficit hyperactivity disorder (ADHD).
- To assess bupropion's tolerability and safety profile in ADHD patients.
- To explore bupropion's potential for treating comorbid conditions alongside ADHD.
Main Methods:
- Literature review of studies investigating bupropion for ADHD.
- Analysis of clinical trial data and observational studies.
- Assessment of reported side effects and patient outcomes.
Main Results:
- Bupropion demonstrates efficacy in treating attention deficit hyperactivity disorder (ADHD) across various age groups.
- The medication is generally well-tolerated, despite some early reports of seizures.
- Bupropion shows promise in managing comorbid conditions such as depression, anxiety, and substance abuse.
Conclusions:
- Bupropion is a viable alternative or adjunct treatment for attention deficit hyperactivity disorder (ADHD), particularly when comorbid conditions are present.
- Its unique pharmacological profile offers benefits beyond traditional ADHD medications.
- Further research may solidify bupropion's role in a comprehensive ADHD treatment strategy.
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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
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