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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Appraisal of the multiple sclerosis functional composite
Ruth Ann Marrie1, Jeffrey A Cohen
1Mellen Center for Multiple Sclerosis Treatment and Research/Area U10, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. marrier@ccf.org
Expert Review of Neurotherapeutics
|October 9, 2009
Summary
Multiple sclerosis functional composite (MSFC) offers a better outcome measure for assessing disease impairment. This study discusses its development, validation, and potential improvements for clinical trials.
Area of Science:
- Neurology
- Clinical Trials
- Disease Assessment
Background:
- Multiple sclerosis (MS) is a chronic neurological disease with variable symptoms and fluctuating progression.
- Accurate outcome measures are crucial for evaluating new MS therapies and clinical trial efficacy.
- Existing measures for MS-related impairment have limitations.
Purpose of the Study:
- To introduce and discuss the development of the Multiple Sclerosis Functional Composite (MSFC).
- To highlight the MSFC's utility as an improved outcome measure for MS clinical trials.
- To explore areas for refinement of the MSFC.
Main Methods:
- Development of a composite outcome measure integrating key functional domains.
- Validation of the MSFC using clinical trial data.
- Analysis of MSFC properties as an assessment tool.
Main Results:
- The MSFC was developed to address the need for better MS outcome measures.
- The MSFC demonstrates desirable features for assessing MS-related impairment.
- The study details the methods for MSFC development and validation.
Conclusions:
- The MSFC represents a significant advancement in measuring MS functional status.
- Further improvements to the MSFC are possible and warranted.
- The MSFC is a valuable tool for current and future MS clinical research.
