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Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
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Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Oral Drug Delivery Systems: Continuous-Release Systems

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Related Experiment Video

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Self-Administration of Drugs in Mouse Models of Feeding and Obesity
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Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

Risperidone long-acting injection.

Pierre Chue1

  • 1Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada. pchue@ualberta.ca

Expert Review of Neurotherapeutics
|October 9, 2009
PubMed
Summary

Risperidone long-acting offers assured medication delivery as the first atypical antipsychotic injection. Its microsphere technology ensures gradual risperidone release for sustained plasma levels.

Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Neuroscience

Background:

  • Risperidone long-acting represents a novel formulation of an atypical antipsychotic.
  • It addresses challenges associated with conventional antipsychotic depot injections.

Purpose of the Study:

  • To introduce the first injectable sustained-action formulation of risperidone.
  • To highlight the advantages of this advanced drug delivery system.

Main Methods:

  • Utilizes microsphere technology encapsulating risperidone in a biodegradable polymer.
  • Employs progressive hydrolysis of microspheres for controlled drug release.

Main Results:

  • Achieves predictable and sustained plasma levels of risperidone.

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  • Ensures assured medication delivery through repeated injections.

    • Conclusions:

    • Risperidone long-acting provides a potentially advantageous atypical antipsychotic treatment option.
    • The microsphere technology facilitates consistent therapeutic drug levels.