Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redox- and Photo-Responsive Fe<sup>3+/2+</sup>-Cross-Linked Carboxymethyl Cellulose Methacrylate Dissipative Gels: Synthesis and Applications.

ACS applied materials & interfaces·2026
Same author

Endoscopic Endonasal Transclival Approach to Ventral Brainstem Cavernous Malformations: Preliminary Case Series and Technical Note on Clival Reconstruction.

World neurosurgery·2026
Same author

State of the art and future perspectives on the management of spheno-orbital meningiomas: a meta-analysis comparing transorbital and transcranial approaches.

Frontiers in oncology·2026
Same author

The role of preoperative medical therapy on prolactin normalization following prolactinoma resection: evaluating longitudinal prolactin trajectories using linear mixed-effects modeling.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2026
Same author

Solid Pro-Nano Lipid Oral Formulations for Cannabidiol (CBD).

Pharmaceutics·2026
Same author

An Assessment of Exposure and Maneuverability to the Upper Parapharyngeal Space Through the Multiport Endoscopic Endonasal Transpterygoid and Anterior Transmaxillary Techniques.

Head & neck·2026

Related Experiment Video

Updated: Jun 19, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Gene therapy for malignant brain tumors.

Gustavo Pradilla1, Tony Azzam, Paul P Wang

  • 1Department of Neurological, Surgery and Oncology, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Hunterian 817, Baltimore, MD 21205, USA. gpradil2@jhmi.edu

Expert Review of Neurotherapeutics
|October 9, 2009
PubMed
Summary

Gene therapy offers a promising approach to treating malignant brain tumors by targeting molecular defects. While challenges with delivery systems remain, ongoing research explores new strategies for improved clinical success in brain cancer treatment.

More Related Videos

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
09:02

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Published on: September 27, 2024

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

Related Experiment Videos

Last Updated: Jun 19, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
09:02

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Published on: September 27, 2024

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genetics

Background:

  • Malignant brain tumors, both primary and metastatic, remain a significant cause of mortality despite advances in diagnostics and conventional therapies.
  • Recent molecular discoveries have enhanced understanding of brain tumor development and opened avenues for novel therapeutic strategies.
  • Gene therapy presents a targeted treatment modality by addressing fundamental molecular defects in malignant cells.

Purpose of the Study:

  • To review the genetic underpinnings of cerebral neoplasms and neurogenetic syndromes.
  • To discuss various gene therapy strategies and DNA delivery systems for brain tumors.
  • To examine the status of clinical trials and future prospects for gene therapy in neuro-oncology.

Main Methods:

  • Literature review of genetic fundamentals, gene therapy strategies, and delivery systems.
  • Analysis of ongoing clinical trials for brain tumor gene therapy.
  • Discussion of future directions and challenges in the field.

Main Results:

  • Gene therapy targets molecular defects in brain tumors, offering a new treatment spectrum.
  • Delivery systems represent a key challenge limiting widespread clinical success.
  • Numerous targets and strategies are under investigation, with ongoing clinical trials exploring their efficacy.

Conclusions:

  • Gene therapy holds significant potential for treating malignant brain tumors by addressing their root molecular causes.
  • Overcoming limitations in DNA delivery systems is crucial for achieving substantial clinical success.
  • Continued research into genetic targets, therapy strategies, and delivery methods is essential for advancing neuro-oncology treatments.