Disulfide-related proteomic studies on food allergens

An increasing proportion of the population is affected by food allergy. Some food allergens ('incomplete' allergens) elicit clinical symptoms only owing to their homology with other allergens, while others ('complete') can both sensitize and elicit clinical symptoms. To challenge food allergy, it should be effective to invest more energy in tackling the complete ones. Post-translational modification proteomics allows a comprehensive investigation of complete allergens. It provides clues to elucidate mechanisms of the structures that contribute to allergenicity, which thus, in turn, to help alleviate food allergens. This review summarizes the recent proteomic challenges to identify and alleviate food allergens, especially through disulfide-related studies.