Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum allopregnanolone in women with postpartum "blues".

Obstetrics and gynecology·2001
Same author

The use of a starting dose of recombinant follicle stimulating hormone for controlled ovarian hyperstimulation: a randomized pilot study.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
Same author

Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
Same author

Ovarian follicular fluid contains immunoreactive estriol: lack of correlation with estradiol concentrations.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
Same author

Dose-response efficacy of a new estradiol transdermal matrix patch for 7-day application: a randomized, double-blind, placebo-controlled study. Italian Menopause Research Group.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology·2000
Same author

Effects of estradiol and raloxifene analog on brain, adrenal and serum allopregnanolone content in fertile and ovariectomized female rats.

Neuroendocrinology·2000
Same journal

The International Menopause Society celebrates another milestone.

Climacteric : the journal of the International Menopause Society·2026
Same journal

Impact of social determinants of health on perimenopause symptom burden: insights from the Flo app.

Climacteric : the journal of the International Menopause Society·2026
Same journal

From tissue to outcome - how perioperative vaginal estrogen transforms prolapse surgery results: a systematic review and meta-analysis of clinical evidence and outcomes.

Climacteric : the journal of the International Menopause Society·2026
Same journal

Mapping menopause education for healthcare professionals: a scoping review.

Climacteric : the journal of the International Menopause Society·2026
Same journal

Portuguese osteopaths' perceptions on the management of musculoskeletal conditions in menopausal women.

Climacteric : the journal of the International Menopause Society·2026
Same journal

Perimenopausal migraine: a narrative review.

Climacteric : the journal of the International Menopause Society·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Androgen replacement therapy and cardiovascular function.

A R Genazzani1, N Pluchino

  • 1Department of Reproductive Medicine and Child Development, Section of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.

Climacteric : the Journal of the International Menopause Society
|October 9, 2009
PubMed
Summary
This summary is machine-generated.

Declining androgens impact women

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Experiment Videos

Last Updated: Jun 19, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Area of Science:

  • Reproductive endocrinology and cardiovascular health in women.

Background:

  • Androgens are crucial for female physiology.
  • Age-related decline in ovarian and adrenal androgen production affects women's health.
  • Limited research exists on androgen deficiency's cardiovascular impact in aging women.

Purpose of the Study:

  • To review the effects of androgens on the female cardiovascular system.
  • To explore androgen deficiency as a potential cardiovascular disease risk factor in aging women.
  • To examine dehydroepiandrosterone and testosterone replacement in postmenopausal women.

Main Methods:

  • Literature review focusing on androgen's cardiovascular effects.
  • Analysis of studies on androgen deficiency and cardiovascular disease risk.
  • Examination of hormone replacement therapy (dehydroepiandrosterone, testosterone) in postmenopausal women.

Main Results:

  • Androgen decline may negatively impact cardiovascular biology in women.
  • Androgen deficiency is being investigated as a risk factor for cardiovascular disease.
  • Hormone replacement therapy is explored for cardiovascular benefits in postmenopausal women.

Conclusions:

  • Androgen's role in female cardiovascular health requires further investigation.
  • Understanding androgen deficiency is vital for women's cardiovascular disease prevention.
  • Hormone replacement may offer therapeutic potential for postmenopausal women's cardiovascular health.