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Treatment with DNAse I fosters binding to nec PBMC of CRP
Christina Janko1, Christine Schorn, Daniela Weidner
1Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany. christina.janko@uk-erlangen.de
Abstract:
CRP is an important inflammatory marker, however, CRP levels are relatively low in patients with SLE. In addition patients with SLE often display low activities and serum levels for DNase I and complement, respectively. Here we show that DNase I treatment of nec PBMC increased their binding of CRP. Consequently, reduced DNase I activity in patients with SLE may contribute to the impaired opsonisation by CRP of dead cells, exacerbating the clearance defect in SLE of apo and nec cells.
