Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2025

Same author

Search for Light Long-Lived Particles in pp Collisions at sqrt[s]=13 TeV Using Displaced Vertices in the ATLAS Inner Detector.

Physical review letters·2024

Same author

Search for the Exclusive W Boson Hadronic Decays W^{±}→π^{±}γ, W^{±}→K^{±}γ and W^{±}→ρ^{±}γ with the ATLAS Detector.

Physical review letters·2024

Same author

Determination of the Relative Sign of the Higgs Boson Couplings to W and Z Bosons Using WH Production via Vector-Boson Fusion with the ATLAS Detector.

Physical review letters·2024

Same author

Studies of the Energy Dependence of Diboson Polarization Fractions and the Radiation-Amplitude-Zero Effect in WZ Production with the ATLAS Detector.

Physical review letters·2024

Same author

Combination of Searches for Higgs Boson Pair Production in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector.

Physical review letters·2024

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

oxLDL/beta2GPI complex and anti-oxLDL/beta2GPI in SLE: prevalence and correlates.

N Bassi¹, S Zampieri, A Ghirardello

¹Divsion of Rheumatology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy.

|October 9, 2009

Summary

High levels of oxidized low-density lipoprotein/beta2 glycoprotein 1 (oxLDL/beta2GPI) complexes and antibodies against them are more common in systemic lupus erythematosus (SLE) patients, potentially contributing to organ damage.

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Related Experiment Videos

Last Updated: Jun 19, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Area of Science:

Immunology
Rheumatology
Cardiovascular Research

Background:

Elevated levels of oxidized low-density lipoprotein/beta2 glycoprotein 1 (oxLDL/beta2GPI) complexes and corresponding antibodies (IgG and IgM) are observed in systemic lupus erythematosus (SLE).
The role of these complexes and antibodies in SLE pathogenesis and their association with clinical manifestations require further investigation.

Purpose of the Study:

To analyze the prevalence and levels of oxLDL/beta2GPI complexes and anti-complex antibodies in SLE patients.
To evaluate the relationship between these markers and clinical/serological findings, atherosclerosis risk factors, and subclinical atherosclerosis in SLE.

Main Methods:

Comparative analysis of oxLDL/beta2GPI complex and anti-complex antibody levels in SLE patients versus normal healthy donors (NHD).
Correlation analysis with clinical data (renal, neurological involvement, thromboembolic episodes), atherosclerosis risk factors, and serological markers (antiphospholipid antibodies).

Main Results:

Significantly higher prevalence and levels of oxLDL/beta2GPI complexes and anti-complex antibodies were found in SLE patients compared to NHD.
Higher titers of oxLDL/beta2GPI complexes were associated with renal involvement and prior thromboembolic events, and correlated with atherosclerosis risk factors.
Lower titers were observed in patients with neurological involvement.
Both IgG and IgM anti-complex antibodies showed an association with antiphospholipid antibodies.

Conclusions:

The oxLDL/beta2GPI complex and antibodies against it are prevalent in SLE patients.
These findings suggest a potential role for oxLDL/beta2GPI complexes and associated antibodies in SLE-related organ damage and cardiovascular complications.