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Updated: Jun 19, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
ACE I/D and G2350A polymorphisms in Pakistani hypertensive population of Punjab
Farrakh M Alvi1, Shahida Hasnain
1Department of Microbiology and Molecular Genetics, University of Punjab, Quaid-e-Azam Campus, Lahore, Pakistan.
Abstract:
Several studies in different populations have shown mixed association of hypertension with ACE I/D and G2350A polymorphisms. To assess the link of these two polymorphisms with hypertension in population of Punjab--most populated province of Pakistan--we carried out this retrospective case control study in a mixed sample of 344 hypertensive and normotensive controls. Genotype of the ACE I/D was determined by nested PCR and G2350A. polymorphism was determined by amplification of a small fragment containing SNP and digesting it with the restriction enzyme. Statistical analysis revealed that I/D polymorphism is not associated with hypertension in the Punjabi population chi(2) (df = 2) = 5.611, P
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