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Related Concept Videos

Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...

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Related Experiment Video

Updated: Jun 19, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Dermatofibrosarcoma protuberance].

Gudjon Leifur Gunnarsson1, Dorthe Mikkelsen, Carsten Sauer Mikkelsen

  • 1Plastikkirurgisk Afdeling, Odense Universitetshospital, DK-5000 Odense. gudjonleifur@yahoo.com

Ugeskrift for Laeger
|October 9, 2009
PubMed
Summary
This summary is machine-generated.

A rare forehead subdermal dermatofibrosarcoma was successfully treated with wide surgical excision and immediate reconstruction. Intraoperative tissue expansion significantly aided defect closure, highlighting its benefit in complex cases.

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Area of Science:

  • Dermatologic Surgery
  • Surgical Oncology
  • Plastic and Reconstructive Surgery

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin cancer.
  • Subdermal presentation of DFSP can pose diagnostic and surgical challenges.
  • Effective management requires complete tumor removal with adequate margins.

Observation:

  • A 33-year-old Caucasian presented with an asymptomatic subdermal dermatofibrosarcoma protuberance on the forehead.
  • The lesion was treated with surgical excision achieving a 3 cm margin.
  • Immediate reconstruction involved intraoperative tissue expansion and full-thickness skin grafting.

Findings:

  • Pathological evaluation confirmed the diagnosis of dermatofibrosarcoma protuberans.
  • Intraoperative tissue expansion reduced the surgical defect by 50%.
  • Successful reconstruction was achieved with full-thickness skin transplantation.

Implications:

  • Emphasizes the critical role of pathological assessment for all resected tissues.
  • Demonstrates the utility of intraoperative tissue expansion in managing large forehead defects.
  • Supports a multidisciplinary approach for optimal outcomes in rare soft tissue tumors.