Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioavailable human metabolites of a keratin-derived hydrolysate promote primary human dermal fibroblast activities and protect against oxidative stress-related damages.

Frontiers in nutrition·2026
Same author

Exploring mitochondrial functions and dysfunctions in chondrocytes: toward the identification of novel therapies for osteoarthritis.

Bone research·2026
Same author

3D Printing of Dense and Anisotropic Collagen/Hyaluronan Hydrogels for Biofabrication of Layered Annulus Fibrosus Tissue.

Biomacromolecules·2026
Same author

A Swiss army knife for the treatment of bone cancers: a new multifunctional platform based upon SPIONs@copper-doped bioactive glass core-shell nanoparticles.

Nanoscale·2026
Same author

Transcriptomic and Functional Comparison of Cells Isolated From Healthy and Degenerated Ovine Intervertebral Discs.

Journal of cellular and molecular medicine·2026
Same author

Characterization of immune cells in periodontitis using a new histological immunologic gingival (IG) score.

Scientific reports·2026

Related Experiment Video

Updated: Jun 19, 2026

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Oxidative stress in bone remodelling and disease.

Fabien Wauquier1, Laurent Leotoing, Véronique Coxam

  • 1Inra, UMR 1019 Nutrition Humaine, F-63122 Saint Genès Champanelle, France.

Trends in Molecular Medicine
|October 9, 2009
PubMed
Summary

Oxidative stress, an imbalance in reactive oxygen species (ROS), significantly impacts bone health. Targeting this redox imbalance may offer new therapeutic strategies for bone diseases.

Related Experiment Videos

Last Updated: Jun 19, 2026

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Area of Science:

  • Biomedical Science
  • Cell Biology
  • Bone Biology

Background:

  • Oxidative stress involves an excess of reactive oxygen species (ROS), disrupting cellular redox balance.
  • ROS are increasingly recognized for their roles in cell function and signaling, beyond aging.
  • Recent findings highlight ROS generation as a critical factor in bone cell activity and mineralized tissue health.

Purpose of the Study:

  • To review the critical role of oxidative stress in bone pathophysiology.
  • To explore the potential of ROS production as a therapeutic target in bone diseases.
  • To assess the future utility of modulating redox balance for bone disease therapies.

Main Methods:

  • Literature review of studies on oxidative stress and bone.
  • Analysis of the impact of ROS on bone cell function.
  • Discussion of therapeutic implications of redox balance manipulation.

Main Results:

  • Oxidative stress significantly influences bone cell function and the pathophysiology of mineralized tissues.
  • ROS generation is a key modulator in bone tissue.
  • The review synthesizes current understanding of oxidative stress in bone.

Conclusions:

  • Oxidative stress plays a crucial role in bone pathophysiology.
  • Targeting ROS production may be a relevant therapeutic strategy for certain bone conditions.
  • Further research is needed to validate redox balance manipulation for future bone disease therapies.