Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Strategies for Maximising Lung Utilisation in Donors After Brain and Cardiac Death: A Narrative Review.

Journal of clinical medicine·2025

Same author

The organ donation process: An ethical commitment.

Medicina intensiva·2024

Same author

Family Refusal to Consent Donation: Retrospective Quantitative Analysis of Its Increasing Tendency and the Associated Factors Over the Last Decade at a Spanish Hospital.

Transplantation proceedings·2021

Same author

Transplantation of a heart donated after circulatory death via thoraco-abdominal normothermic regional perfusion and results from the first Spanish case.

Journal of cardiothoracic surgery·2020

Same author

Implementation of a mobile team to provide normothermic regional perfusion in controlled donation after circulatory death: Pilot study and first results.

Clinical transplantation·2020

Same author

[Factors affecting the survival of transplants from donors after prehospital cardiac death].

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias·2017

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

[Organ preservation].

José Luis Escalante Cobo¹, Francisco Del Río Gallegos

¹Programa de Trasplantes, Hospital General Universitario Gregorio Marañón, Madrid, España. joseluis.escalante@salud.madrid.org

Medicina Intensiva

|October 9, 2009

Summary

Organ preservation is vital for transplant success. Continuous machine perfusion offers a promising alternative to static cold storage for maintaining organ viability, especially for expanded criteria donors facing increased compromise.

Area of Science:

Transplantation Science
Organ Preservation
Ischemia-Reperfusion Injury

Context:

Organ transplantation is vital for end-stage organ failure.
Donor shortages necessitate expanded donor criteria, leading to compromised organs.
Ischemia-reperfusion injury significantly impacts graft outcomes.

Purpose:

To review current organ preservation techniques.
To highlight the challenges in maintaining viability for expanded criteria donor organs.
To emphasize continuous machine perfusion as an advanced preservation method.

Summary:

Organ viability preservation is essential for graft success.
Static cold storage, while common, may be insufficient for compromised organs.
Continuous machine perfusion is presented as a superior technique for optimizing organ quality.

More Related Videos

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Published on: January 12, 2019

Related Experiment Videos

Last Updated: Jun 19, 2026

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Published on: January 12, 2019

Impact:

Improved organ preservation strategies can enhance transplant success rates.
Advanced techniques like machine perfusion may expand the donor pool.
Minimizing ischemia-reperfusion injury is key to long-term graft function.