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CD47 and TLR-2 cross-talk regulates neutrophil transmigration

Alex C Chin1, Bénédicte Fournier, Eric J Peatman

  • 1Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA. achin@emory.edu

Journal of Immunology (Baltimore, Md. : 1950)
|October 9, 2009
PubMed
Summary

Toll-like receptor 2 (TLR2) and CD47 costimulation enhance neutrophil transmigration during acute inflammation. This interaction boosts the sensitivity of neutrophils to TLR2 activation, aiding their movement to infection sites for pathogen removal.

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