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Updated: Jun 19, 2026
11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Immunosuppression in high-risk transplantation.
Jason Rhee1, Nora Al-Mana, Richard Freeman
1Department of Surgery, Tufts Medical Center, Boston, Massachusetts 02111, USA.
Current Opinion in Organ Transplantation
|October 9, 2009
Summary
Optimizing immunosuppression for high-risk kidney transplants is crucial. Current protocols show promise short-term but lack long-term data for donor or recipient risk factors, posing a challenge for clinicians.
Area of Science:
- Nephrology
- Transplantation Immunology
Background:
- High-risk kidney transplant candidates present challenges due to increased risks of graft failure.
- Donor grafts may also carry inherent risks, complicating management.
Purpose of the Study:
- To review current immunosuppressive strategies for high-risk kidney transplant recipients.
- To understand the role of immunosuppression in optimizing outcomes for these complex cases.
Main Methods:
- Review of existing clinical trials on immunosuppressive protocols in high-risk renal transplantation.
- Categorization of risks based on donor organ quality and recipient immunological factors.
Main Results:
- Few immunosuppressive protocols are rigorously tested in high-risk kidney transplant settings.
- Protocols focus on reducing nephrotoxic drugs for donor-related risks or using lymphocyte-depleting agents for recipient-related immunological risks.
- Acceptable short-term outcomes have been observed with current approaches.
Conclusions:
- Long-term outcome data for high-risk kidney transplants, considering both donor and recipient factors, are lacking.
- Developing optimized immunosuppressive regimens tailored to specific risk profiles remains a significant clinical and research challenge.
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