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Naturalistic Observations02:30

Naturalistic Observations

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If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
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Archival Research01:40

Archival Research

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Some researchers gain access to large amounts of data without interacting with a single research participant. Instead, they use existing records to answer various research questions. This type of research approach is known as archival research. Archival research relies on looking at past records or data sets to look for interesting patterns or relationships. For example, a researcher might access the academic records of all individuals who enrolled in college within the past ten years and...
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Blind Procedures02:07

Blind Procedures

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
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Ethics in Research01:56

Ethics in Research

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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Blinding01:11

Blinding

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Related Experiment Video

Updated: May 2, 2026

Blue-hazard-free Candlelight OLED
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Blue-hazard-free Candlelight OLED

Published on: March 19, 2017

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The most transparent research.

Melinda Wenner

    Nature Medicine
    |October 9, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Scientists are developing methods to make biological tissues transparent, enabling real-time in vivo imaging. This breakthrough will revolutionize disease study and biological development observation.

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    Area of Science:

    • Biomedical Engineering
    • Biophysics
    • Developmental Biology

    Background:

    • Current limitations in biomedical research stem from the opacity of biological tissues, hindering in vivo imaging.
    • Light scattering due to varying refractive indices within tissues prevents clear visualization of internal structures.

    Discussion:

    • Researchers are employing interdisciplinary approaches, integrating genetics, electrical engineering, chemistry, and physics to achieve tissue transparency.
    • The development of transparent organisms, like the "casper" zebrafish, has already enabled real-time studies of cancer pathology and development.

    Key Insights:

    • Overcoming light scattering is crucial for rendering biological tissues transparent.
    • Transparent tissues would allow direct observation of biological processes, akin to observing jellyfish.

    Outlook:

    • Advancements in tissue transparency promise to significantly enhance our understanding of biology and disease.
    • This technology holds potential for improved diagnostics and more effective disease treatment strategies.