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Updated: Jun 19, 2026

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
Published on: March 13, 2016
What does the retrosplenial cortex do?
Seralynne D Vann1, John P Aggleton, Eleanor A Maguire
1School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK. vannsd@Cardiff.ac.uk
Abstract:
The past decade has seen a transformation in research on the retrosplenial cortex (RSC). This cortical area has emerged as a key member of a core network of brain regions that underpins a range of cognitive functions, including episodic memory, navigation, imagination and planning for the future. It is now also evident that the RSC is consistently compromised in the most common neurological disorders that impair memory. Here we review advances on multiple fronts, most notably in neuroanatomy, animal studies and neuroimaging, that have highlighted the importance of the RSC for cognition, and consider why specifying its precise functions remains problematic.
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