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Published on: August 16, 2017
A comprehensive analysis of gene expression evolution between humans and mice
1Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.
Evolutionary Bioinformatics Online
|October 9, 2009
Summary
Gene expression evolution between humans and mice shows conservation in key biological processes, suggesting negative selection. Promoter evolution has a minor effect on gene expression changes.
Area of Science:
- Genomics
- Evolutionary Biology
- Molecular Biology
Background:
- Phenotypic differences between species largely stem from evolutionary changes in gene expression.
- Microarray technology enables systematic studies of gene expression evolution.
Purpose of the Study:
- Compare gene expression patterns between human and mouse genomes.
- Investigate the relationship between gene expression evolution and Gene Ontology (GO) terms.
- Decode the link between promoter evolution and gene expression evolution.
Main Methods:
- Utilized two published methods for comparative gene expression analysis.
- Analyzed gene expression patterns across human and mouse genomes.
- Assessed promoter conservation using a motif-count score.
Main Results:
- Significant enrichment of biological processes in conserved gene expression indicates functional importance and negative selection.
- Fast-evolving genes support a neutral model for gene expression evolution.
- Gene expression conservation shows a slight positive correlation with promoter conservation.
Conclusions:
- Gene expression evolution between humans and mice is best described by a neutral model with negative selection.
- Promoter evolution may influence gene expression evolution, though the effect is limited.
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