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Hemangioma of the mandible: case report with special emphasis on bone degradation
Torsten Hansen1, Martin Kunkel, Detlef Katenkamp
1Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany. hansen@pathologie.klinik.uni-mainz.de
Purpose:
Intraosseous hemangioma of the mandible is a rare tumor. In this report, we present a case with a particularly prominent osteolysis and discuss the histological features of bone degradation.
Materials And Methods:
We describe a 64-year-old female patient with a cystic tumor mass of the mandible leading to pathologic bone fracture. X-ray analysis was suggestive for aneurysmatic bone cyst. A segment resection was performed.
Results:
The histological examination revealed a mesenchymal tumor with numerous capillaries and dilated vessels immunohistochemically being positive for CD31, but not for D2-40. In addition, there was a remarkable increase of osteoclasts that sometimes exhibited Howship's lacunae. The tumor was diagnosed as intraosseous hemangioma with prominent bone degradation.
Conclusions:
Based on our histological findings, it should be further investigated whether there could be an association between angiogenesis and osteoclastogenesis as a central pathway leading to bone destruction in the case of intraosseous hemangiomas.
