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Updated: Jun 19, 2026
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Characteristics of embryo development in Robertsonian translocations' preimplantation genetic diagnosis cycles
Jin Huang1, Ying Lian, Jie Qiao
1Reproductive Medicine Center, Peking University Third Hospital, Beijing 100191, China.
Objective:
To explore the embryo development characteristics in Robertsonian translocations (RTs) in their preimplantation genetic diagnosis (PGD) cycles.
Method:
A total of 37 RT carrier couples underwent 41 blastomere PGD cycles from August 2005 to September 2008. The development of 272 embryos was analyzed in their PGD cycles.
Result(S):
At D3, there were 161 high-grade embryos, including 59 normal/balanced embryos and 102 abnormal embryos. There was no difference between the normal/balanced embryo group and the abnormal embryo group in terms of the high-grade embryo percentage (64.84% vs 56.35%, p = 0.179). However, at D5-D6, the blastocyst percentage in the normal/balanced embryo group was significantly higher than that in the abnormal embryo group (43.96% vs 20.44%, p = 0.000).
Conclusion(S):
Normal/balanced embryos developed better and a self-selective mechanism may exist in the RTs' embryos at the blastocyst formation stage.
