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Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis
L Vécsei1, B Csala, E Widerlöv
1Department of Psychiatry and Neurochemistry, University of Lund, Sweden.
Brain Research Bulletin
|September 1, 1990
Abstract:
The cerebrospinal fluid (CSF) concentrations of somatostatin and neuropeptide Y were investigated by use of radioimmunoassay in patients suffering from chronic progressive multiple sclerosis. The somatostatin level was significantly decreased in the CSF of patients with multiple sclerosis compared to the control group. The magnitude of this change was more pronounced in patients with severe clinical symptoms of the illness. The CSF neuropeptide Y concentration did not differ from the control values. These findings suggest a selective involvement of somatostatin neurotransmission in multiple sclerosis.