Related Experiment Video
Updated: Jun 19, 2026

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
Developmental pathways leading to obesity in childhood
Samar Hejazi1, V Susan Dahinten, Sheila K Marshall
1School of Nursing, University of British Columbia, Vancouver, British Columbia V2Y 1Y1. Samar.Hejazi@nursing.ubc.ca
Background:
Researchers have yet to provide a comprehensive explanation of the variability in the development of childhood obesity, owing in part to the dearth of longitudinal studies. Such an understanding would contribute to the improvement of approaches for the primary and secondary prevention of childhood obesity. This study identifies, in a representative sample of Canadian children, age-related patterns of overweight and obesity between toddlerhood and childhood.
Data And Methods:
The data are from cycles 2 through 5 (1996/1997 to 2002/2003) of the National Longitudinal Survey of Children and Youth. The sample comprised children aged 24 to 35 months at baseline, who were followed biennially over six years. Group-based mixture modelling analyses (using SAS PROC TRAJ) were conducted to identify the sex-specific developmental trajectories of body mass index (BMI).
Results:
Group-based modelling identified four BMI trajectories for the girls (stable normal BMI, early declining BMI, late declining BMI, and an accelerating rise to obesity) and three for the boys (stable normal BMI, transient high BMI, and a J-curve rise to obesity).
Interpretation:
Identifying distinct, sex-specific BMI trajectories is valuable in understanding pathways through which a child may develop obesity. These findings have implications for further research and practice, in particular, that no single approach can be used to prevent or reduce levels of obesity.
Related Concept Videos
Obesity
Type II Diabetes I: Introduction
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Regulation of Food Intake
Type II Diabetes II: Pathophysiology

