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Related Experiment Video

Updated: Jun 19, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

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Published on: November 14, 2017

[Relationship between apolipoprotein E polymorphism and cognitive function in patients with primary hypertension].

Yanling Su1, Xiaoping Chen, Yan Huang

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|October 10, 2009
PubMed
Summary

The apolipoprotein E epsilon4 allele and age are risk factors for cognitive impairment in hypertensive patients. Specifically, the epsilon4/4 genotype is linked to a higher risk of cognitive decline in this population.

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Area of Science:

  • Neuroscience
  • Genetics
  • Cardiology

Context:

  • Primary hypertension is a prevalent condition associated with cognitive decline.
  • Apolipoprotein E (ApoE) gene polymorphism is implicated in various neurological disorders.
  • Understanding genetic predispositions can aid in identifying at-risk hypertensive individuals.

Purpose:

  • To investigate the association between apolipoprotein E (ApoE) gene polymorphism and cognitive function in Chinese patients with primary hypertension.
  • To identify specific ApoE genotypes and alleles that correlate with cognitive impairment in this cohort.

Summary:

  • This study analyzed 200 Chinese primary hypertension patients, assessing cognitive function using the Mini Mental State Examination (MMSE). Apolipoprotein E polymorphism was determined using PCR-RELP.
  • Results indicated significantly higher frequencies of ApoE epsilon3/4 and epsilon4/4 genotypes, and the e4 allele in patients with cognitive impairment compared to those with normal cognition.
  • Age and the epsilon4/4 genotype showed a positive correlation with hypertensive-cognitive impairment, while higher cultural levels correlated negatively.

Impact:

  • ApoE epsilon4 allele and advanced age are identified as potential risk factors for cognitive impairment in hypertensive individuals.
  • The epsilon4 homozygote (epsilon4/4) genotype may significantly influence the progression of cognitive impairment in primary hypertension.
  • Findings contribute to understanding the genetic underpinnings of cognitive decline in hypertension, potentially informing targeted interventions.