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Updated: Jun 19, 2026

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
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Myotonic dystrophy and pregnancy

Zainab Ashraf Khan1, Shahid Aziz Anwer Khan

  • 1West Cumberland Hospital, Whitehaven, United Kingdom.

JPMA. the Journal of the Pakistan Medical Association
|October 10, 2009
PubMed

Myotonic dystrophy is the most common neuromuscular disease in adults with a prevalence of 2.4-5.5 per 100,000. Here we describe two cases of DM and discuss their obstetric complications. Our first case concerns a 39 year old multipara whose pregnancies were complicated by recurrent abdominal pain, polyhydramnios and post partum haemorrhage which was attributed to DM. In our second case we discuss the management of a 27 year old woman with dichorionic, di-amniotic twins. Chorionic Villous Sampling at 11 weeks revealed one of the fetuses, a male; to be afflicted by DM. Selective termination of the affected twin was performed. Unfortunately, she developed severe oligohydramnios and chronic liquor leak. This resulted in the intra-uterine death of the second twin 5 days later. Our cases highlight the importance of prenatal diagnosis and prompt genetic counselling. A multidisciplinary team approach is required in the management of such high risk cases.

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