Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship Between Cerebral Oximetry and Outcomes in Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis.

Critical care explorations·2026
Same author

Sex differences in brain frailty measures and outcomes after endovascular thrombectomy: ESCAPE-NA1 analysis.

Journal of the neurological sciences·2026
Same author

Association of Successful Recanalization and Functional Outcomes in Minor Ischemic Stroke With Proven Occlusion: A Secondary Analysis of TEMPO-2 Trial.

Stroke·2026
Same author

Prevalence, semiology and neuroimaging of movements in comatose adults at risk of death by neurologic criteria: a prospective cohort study.

Critical care (London, England)·2026
Same author

Association of glomerular hyperfiltration with mortality in stroke: an analysis using pooled individual patient data.

European stroke journal·2026
Same author

AcT Trial: Protocol for a Pragmatic Registry-Linked Randomized Clinical Trial.

Stroke (Hoboken, N.J.)·2026
Same journal

Prosthetic valve thrombosis: contemporary concepts in diagnosis and management.

Expert review of cardiovascular therapy·2026
Same journal

Life's essential 8 and its role in cardiovascular health: evolution, evidence, and future directions.

Expert review of cardiovascular therapy·2026
Same journal

Efficacy and safety of clopidogrel and aspirin initiated within 72 hours after mild ischemic stroke or high-risk TIA by sex: a prespecified subgroup analysis of the INSPIRES trial.

Expert review of cardiovascular therapy·2026
Same journal

Approaches to transcatheter aortic valve replacement failure: is more focus on prevention required?

Expert review of cardiovascular therapy·2026
Same journal

Vericiguat for heart failure with reduced ejection fraction: a perspective from approval to real-world clinical treatment.

Expert review of cardiovascular therapy·2026
Same journal

Early autonomic neuropathy in prediabetes: an overlooked driver of cardiometabolic risk.

Expert review of cardiovascular therapy·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Predicting recurrent stroke after minor stroke and transient ischemic attack.

Philippe Couillard1, Alexandre Y Poppe, Shelagh B Coutts

  • 1Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.

Expert Review of Cardiovascular Therapy
|October 10, 2009
PubMed
Summary
This summary is machine-generated.

Patients experiencing a transient ischemic attack or minor stroke face a high risk of recurrent stroke. Early brain imaging and identifying the stroke cause are crucial for tailored management and preventing future events.

Related Experiment Videos

Last Updated: Jun 19, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Area of Science:

  • Neurology
  • Stroke Medicine
  • Diagnostic Imaging

Background:

  • Acute transient ischemic attack (TIA) and minor stroke carry a significant risk of subsequent stroke, with approximately 10% occurring within 90 days.
  • Identifying high-risk patients is essential for implementing targeted management strategies to prevent recurrent events.

Purpose of the Study:

  • To review predictors of recurrent stroke after TIA or minor stroke.
  • To emphasize the importance of early diagnostic imaging and etiological investigation for risk stratification and personalized treatment.

Main Methods:

  • Review of recent literature on predictors of recurrent stroke.
  • Focus on the role of ABCD2 score, brain parenchyma imaging (diffusion-weighted imaging), vascular imaging, and stroke mechanism identification.

Main Results:

  • Predictors such as ABCD2 score, brain imaging findings, and stroke mechanism influence recurrent stroke risk.
  • Early diffusion-weighted imaging and vascular imaging are critical for identifying high-risk individuals.

Conclusions:

  • Risk stratification following TIA or minor stroke is vital for guiding management decisions, including hospital admission versus emergency room discharge.
  • Tailoring therapies based on the identified cause of the initial event is paramount for effective secondary stroke prevention.