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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Phase I Reactions: Reductive Reactions01:27

Phase I Reactions: Reductive Reactions

Phase I biotransformation reductive reactions are chemical processes that modify drugs by introducing or revealing polar functional groups via reduction. Enzymes called reductases catalyze these reactions, playing a pivotal role in drug metabolism by transforming lipophilic drugs into more polar, water-soluble metabolites for easy excretion. An essential type of reductive reaction is the carbonyl group reduction, where aldehydes and ketones are reduced to alcohols. An example is the...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...

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Related Experiment Videos

An effective approach to decrease antipsychotic and benzodiazepine use in nursing homes: the RedUSe project.

Juanita Westbury1, Shane Jackson, Peter Gee

  • 1Unit for Medication Outcomes, Research and Education (UMORE), School of Pharmacy, University of Tasmania, Hobart, Tasmania, Australia. Juanita.Westbury@utas.edu.au

International Psychogeriatrics
|October 10, 2009
PubMed
Summary
This summary is machine-generated.

The RedUSe project successfully reduced benzodiazepine and antipsychotic use in nursing homes through a pharmacist-led intervention. This initiative demonstrated significant decreases in resident psychotropic medication and increased dose reductions.

Related Experiment Videos

Area of Science:

  • Geriatric Pharmacy
  • Pharmacoeconomics
  • Clinical Pharmacology

Background:

  • Nursing home residents frequently use psychotropic medications like benzodiazepines and antipsychotics.
  • Reducing the use of these medications is crucial for improving resident safety and quality of life.

Purpose of the Study:

  • To evaluate the effectiveness of the RedUSe (Reducing Use of Sedatives) project, an interdisciplinary intervention aimed at decreasing benzodiazepine and antipsychotic use in nursing homes.
  • To assess the impact of pharmacist-led strategies on psychotropic medication prescribing patterns in aged care facilities.

Main Methods:

  • A controlled trial involving 25 nursing homes in Tasmania, with 13 intervention and 12 control sites.
  • Intervention homes received pharmacist-led strategies including medication audits, feedback, staff education, and interdisciplinary reviews.
  • Psychotropic drug use was monitored using a customized computer program at baseline, 12, and 26 weeks.

Main Results:

  • A significant reduction in the percentage of residents regularly taking benzodiazepines (31.8% to 26.9%) and antipsychotics (20.3% to 18.6%) in intervention homes.
  • Control homes showed no significant changes in psychotropic drug use over the trial period.
  • Significantly higher rates of benzodiazepine and antipsychotic dose reduction or cessation were observed in intervention homes compared to control homes.

Conclusions:

  • The RedUSe project effectively reduced the proportion of nursing home residents using benzodiazepines and antipsychotics.
  • A multi-faceted, community pharmacy-coordinated program can be an effective strategy for reducing psychotropic medication use in nursing homes.
  • Findings support the implementation of similar interventions to optimize psychotropic prescribing in aged care settings.