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Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antiasthma Drugs: Muscarinic Receptor Antagonists01:20

Antiasthma Drugs: Muscarinic Receptor Antagonists

Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.

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Long-term Outcomes of Balloon Dilation for Persistent Eustachian Tube Dysfunction.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2019
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A Randomized Controlled Trial of Balloon Dilation as a Treatment for Persistent Eustachian Tube Dysfunction With 1-Year Follow-Up.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2018
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REMODEL larger cohort with long-term outcomes and meta-analysis of standalone balloon dilation studies.

The Laryngoscope·2015
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Balloon dilatation of the paranasal sinuses: a tool in sinus surgery.

Otolaryngologic clinics of North America·2009
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Effects of ototopical antihistamine on otitis media in an allergic rat.

The Laryngoscope·2007
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Effects of ototopic steroid and NSAIDS in clearing middle ear effusion in an animal model.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2006
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Updated: Jun 19, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Otitis media and antihistamines.

Timothy Goodrich, Frank Rubio, Jeffrey L Cutler

    Current Allergy and Asthma Reports
    |October 10, 2009
    PubMed
    Summary

    Second-generation antihistamines may effectively treat otitis media with effusion (OME) and acute otitis media (AOM). Further research is needed to confirm if these drugs can reduce antibiotic use and surgical interventions for ear infections.

    Area of Science:

    • Otolaryngology
    • Allergy and Immunology
    • Pediatric Medicine

    Background:

    • Otitis media with effusion (OME) and acute otitis media (AOM) are common causes of morbidity and significant healthcare costs in the US.
    • Antihistamine efficacy for OME/AOM is largely refuted, with most studies using older, first-generation agents.
    • First-generation antihistamines often have anticholinergic side effects and lower receptor selectivity.

    Purpose of the Study:

    • To investigate the potential efficacy of second-generation antihistamines in treating OME and AOM.
    • To explore whether second-generation antihistamines offer advantages over first-generation agents due to improved receptor selectivity and reduced anticholinergic activity.

    Main Methods:

    • Review of existing literature on antihistamine use for OME/AOM.

    Related Experiment Videos

    Last Updated: Jun 19, 2026

    Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
    03:40

    Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

    Published on: December 20, 2024

  • Analysis of the pharmacological differences between first- and second-generation antihistamines.
  • Proposal for future clinical trials to assess second-generation antihistamine efficacy.
  • Main Results:

    • Previous studies using first-generation antihistamines have largely failed to demonstrate efficacy for OME/AOM.
    • Second-generation antihistamines possess greater histamine receptor selectivity and lack anticholinergic properties.
    • These characteristics suggest a potential for improved therapeutic outcomes in OME/AOM treatment.

    Conclusions:

    • Second-generation antihistamines represent a potential therapeutic avenue for OME/AOM.
    • If proven effective, these agents could decrease reliance on antibiotics and surgical procedures.
    • Further clinical trials are warranted to validate the efficacy of second-generation antihistamines for otitis media.