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Related Experiment Video

Updated: Jun 19, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

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Late-acquired incomplete stent apposition: morphologic characterization.

Seung-Ho Hur1, Junya Ako, Yasuhiro Honda

  • 1Center for Cardiovascular Technology, Stanford University Medical Center, Stanford, CA 94305-5637, USA.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|October 10, 2009
PubMed
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Late acquired incomplete stent apposition (ISA), a gap between stents and vessel walls seen on intravascular ultrasound (IVUS), occurs more with drug-eluting stents (DES). This finding may link to adverse cardiac events.

Area of Science:

  • Cardiovascular Research
  • Medical Imaging
  • Interventional Cardiology

Background:

  • Incomplete stent apposition (ISA) is the lack of contact between implanted stents and the vessel wall, typically assessed by intravascular ultrasound (IVUS).
  • Late-acquired ISA, developing after initial complete apposition, is an uncommon finding observed with various stent types, including bare-metal stents (BMS) and drug-eluting stents (DES).
  • This phenomenon appears more prevalent with DES compared to BMS implantation.

Purpose of the Study:

  • To review the incidence, location, pathology, and clinical implications of late-acquired ISA.
  • To focus on late-acquired ISA specifically in the context of drug-eluting stent implantation.

Main Methods:

  • Review of existing literature and IVUS findings related to incomplete stent apposition.

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Last Updated: Jun 19, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

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Published on: May 14, 2013

Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model
09:46

Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model

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  • Analysis of reported cases and potential mechanisms contributing to late-acquired ISA.

    • Main Results:

    • Late-acquired ISA is an unusual IVUS finding that can occur after BMS and DES implantation.
    • Vascular remodeling and thrombus dissolution are proposed mechanisms for late-acquired ISA.
    • Late-acquired ISA is observed more frequently with DES than BMS.
    • Conflicting data exists on the clinical impact, but recent DES studies suggest a link to late adverse cardiac events, including stent thrombosis.

    Conclusions:

    • Late-acquired ISA is a notable IVUS finding, particularly with DES.
    • Understanding the mechanisms and clinical sequelae of late-acquired ISA is crucial for patient outcomes.
    • Further research is needed to clarify the association between late-acquired ISA and adverse cardiac events, especially with DES.