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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Stomal complications in the newborn with necrotizing enterocolitis
Pablo Aguayo1, Jason D Fraser, Susan Sharp
1Department of Surgery, The Children's Mercy Hospital and Clinics, Kansas City, Missouri 64108, USA.
The Journal of Surgical Research
|October 10, 2009
Summary
Infants undergoing fecal diversion for necrotizing enterocolitis (NEC) have a high rate of stoma complications. Premature infants, especially those with lower gestational age and weight, face increased risks, necessitating further research into preventative strategies.
Area of Science:
- Neonatal surgery
- Pediatric surgery
- Gastroenterology
Background:
- Necrotizing enterocolitis (NEC) management often involves fecal diversion with stoma creation.
- Clinical observations suggest a high rate of complications associated with stomas in NEC patients.
- This study aims to quantify stoma complication rates and identify associated risk factors.
Purpose of the Study:
- To determine the incidence of stoma-related complications in infants treated for NEC.
- To identify demographic and preoperative factors predicting stoma complications in this population.
Main Methods:
- Retrospective review of 73 infants undergoing laparotomy for NEC between May 1999 and May 2008.
- Data collected included gestational age, birth weight, age at surgery, surgical procedure, and stoma-related outcomes.
- Statistical analysis employed chi-squared, Pearson's correlation, Fisher's exact test, and Student's t-test (P<0.05 significance).
Main Results:
- 42% of patients (31/73) experienced 32 stoma-related complications.
- Lower gestational age (P=0.003) and lower preoperative weight (P=0.024) were significant predictors of stoma complications.
- The most common indication for surgery was pneumoperitoneum (58%), and the ileum was the most common diversion site (85%).
Conclusions:
- Infants with NEC requiring stoma creation are at significant risk of stoma-related complications.
- Premature infants, particularly those with lower gestational age and preoperative weight, face a heightened risk.
- Further prospective research is needed to develop preventative measures for stoma complications in this vulnerable group.
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