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Updated: Jun 19, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Paediatric features of Dengue and Chikungunya fevers]
1Service de néonatologie, réanimation néonatale et pédiatrique, pôle Femme-Mère-Enfant, groupe hospitalier Sud Réunion, centre hospitalier régional, BP 350, 97448 Saint-Pierre cedex, Réunion. patrick.gerardin@chr-reunion.fr
Insights
Dengue and Chikungunya are spreading globally due to adaptable viruses and mosquito vectors. This review covers their life cycle, spread, clinical features, and prevention strategies.
Area of Science:
- Arbovirology
- Infectious Diseases
- Epidemiology
Context:
- Dengue (Df) and Chikungunya fever (Cf) are significant global arboviral diseases.
- The plasticity of RNA viruses and Aedes mosquito vectors contributes to their spread.
- Challenges exist in achieving herd immunity and effective vaccination.
Purpose:
- To review the viral life cycle and epidemiology of Dengue and Chikungunya.
- To discuss pathogenesis and pediatric clinical manifestations.
- To outline basic principles of treatment and prevention.
Summary:
- This review details the viral life cycle and epidemiology of Dengue and Chikungunya.
- It covers pathogenesis, pediatric aspects, and clinical forms of these arboviruses.
- Basic principles for treatment and prevention are also summarized.
Impact:
- Provides a comprehensive overview for understanding and managing Dengue and Chikungunya.
- Highlights challenges in disease control due to viral and vector adaptability.
- Informs public health strategies for arbovirus prevention and treatment.
Abstract:
Dengue (Df) and Chikungunya fever (Cf) arbovirosis are booming in the world, because of the plasticity of their pathogens, mutant RNA viruses making the acquisition of sustainable herd immunity and vaccination difficult in humans, and the plasticity of their vectors, the female mosquitoes of the genus Aedes (Stegomya), capable of adapting to different environments. This review summarizes the viral life cycle and epidemiology of these arboviruses, pathogenesis and pediatric aspects of their clinical forms and the basic principles of their treatment and prevention.
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