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Inhibition of viral carcinogenesis by Phyllanthus amarus

Kuzhuvelil B Harikumar1, Girija Kuttan, Ramadasan Kuttan

  • 1Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India. kbharikumar@gmail.com

Integrative Cancer Therapies
|October 10, 2009
PubMed

Insights

Phyllanthus amarus extract extended survival and reduced anemia in mice with Friend murine leukemia virus (FMuLv)-induced erythroleukemia. This natural compound suppressed viral cancer progression by modulating key gene expressions.

Area of Science:

  • Oncology
  • Virology
  • Pharmacology

Background:

  • Friend murine leukemia virus (FMuLv) causes erythroblastosis and leukemia in mice, serving as a model for antiviral research.
  • Phyllanthus amarus is a plant with known anti-cancer properties in chemically induced models.

Purpose of the Study:

  • To evaluate the efficacy of Phyllanthus amarus extract against FMuLv-induced erythroleukemia in BALB/c mice.
  • To assess the impact of Phyllanthus amarus on leukemia progression, survival rates, and anemia.

Main Methods:

  • BALB/c mice were infected with FMuLv and treated with Phyllanthus amarus extract.
  • Evaluations included hematological, biochemical, histopathological, and gene expression analyses.
  • Specific focus on spleen tissue to assess leukemic cell infiltration and molecular changes.

Main Results:

  • Phyllanthus amarus administration significantly enhanced lifespan and decreased anemia in FMuLv-infected mice.
  • The extract reduced the progression of erythroleukemia and leukemic cell infiltration in the spleen.
  • Gene expression analysis showed increased p53 and p45NFE2, and decreased Bcl-2 in treated mice.

Conclusions:

  • Phyllanthus amarus extract demonstrates significant potential in suppressing virally induced erythroleukemia.
  • The findings suggest Phyllanthus amarus can inhibit viral oncogenesis, expanding its therapeutic relevance.
  • This study supports Phyllanthus amarus as a candidate for further investigation in antiviral and anti-cancer therapies.

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