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Related Experiment Video

Updated: Jun 19, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Transcriptomic analysis of human lung development.

Alvin T Kho1, Soumyaroop Bhattacharya, Kelan G Tantisira

  • 1Children's Hospital Informatics Program, Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA.

American Journal of Respiratory and Critical Care Medicine
|October 10, 2009
PubMed
Summary

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This study maps gene expression during human lung development, revealing new molecular phases and early surfactant gene activity. Our findings provide a detailed view of early lung development beyond animal models.

Area of Science:

  • Genomics
  • Developmental Biology
  • Molecular Biology

Background:

  • Human lung development understanding is limited, primarily based on animal models.
  • Detailed molecular insights into early human lung formation are scarce.

Purpose of the Study:

  • To define global gene expression patterns throughout human lung development.
  • To identify key molecular regulators and developmental stages.

Main Methods:

  • Genome-wide expression profiling of 38 human lung tissues (53-154 days postconception).
  • Principal component analysis for global variation and attribute identification.
  • Quantitative reverse transcriptase-polymerase chain reaction for validation.

Main Results:

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Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
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Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Published on: June 30, 2010

Automated Vibratome Sectioning of Agarose-Embedded Lung Tissue for Multiplex Fluorescence Imaging
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Automated Vibratome Sectioning of Agarose-Embedded Lung Tissue for Multiplex Fluorescence Imaging

Published on: October 6, 2023

Related Experiment Videos

Last Updated: Jun 19, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
07:32

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Published on: June 30, 2010

Automated Vibratome Sectioning of Agarose-Embedded Lung Tissue for Multiplex Fluorescence Imaging
07:17

Automated Vibratome Sectioning of Agarose-Embedded Lung Tissue for Multiplex Fluorescence Imaging

Published on: October 6, 2023

  • Identified novel associations, including chemokine-immunologic processes in lung development.
  • Observed lung characteristic attributes, like surfactant function, earlier than expected.
  • Defined a 3,223-gene subtranscriptome and a time-contiguous expression trajectory with molecular substages.
  • Validated individual gene patterns and accurately predicted developmental age.

Conclusions:

  • Expanded knowledge of gene expression and bioontologic attributes in early human lung development.
  • Suggests the existence of distinct molecular phases during lung development.
  • Provides a foundational dataset for future research into lung development and disease.