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Updated: Jun 19, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Statins as anti-arrhythmics: a systematic review part II: effects on risk of ventricular arrhythmias
Hussam Abuissa1, James H O'Keefe, Kevin A Bybee
1University of Missouri, Kansas City, Missouri, USA. abuissa.hussam@mayo.edu
Background:
Recent studies have demonstrated that statins may possess anti-arrhythmic properties in addition to their lipid-lowering effects.
Methods:
Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature.
Results:
Statins have been associated with a significant reductions in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed.
Conclusions:
Published data suggests that statins may possess anti-arrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.
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