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Related Experiment Video

Updated: Jun 19, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

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Published on: August 15, 2016

Associative network based on cyclodextrin polymer: a model system for drug delivery.

Anne-Magali Layre¹, Gisèle Volet, Véronique Wintgens

¹Systèmes Polymères Complexes, ICMPE, UMR 7182, 2 rue Henrí Dunant, 94320 Thiais, France.

Biomacromolecules

|October 13, 2009

Summary

This study developed polymer networks using cyclodextrin and adamantyl-dextran for drug delivery. These networks show controlled release of benzophenone, influenced by pH and polymer interactions.

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Published on: October 17, 2013

Area of Science:

Polymer Chemistry
Supramolecular Chemistry
Materials Science

Background:

Associative polymer networks offer tunable properties for applications like drug delivery.
Understanding polymer-polymer interactions is crucial for designing functional materials.

Purpose of the Study:

To create and characterize novel associative polymer networks.
To investigate the influence of pH and ionic strength on network properties.
To evaluate the drug loading and release capabilities of the developed networks.

Main Methods:

Synthesis of cyclodextrin-based polymers and adamantyl-functionalized dextran.
Characterization of polymer interactions using isothermal titration microcalorimetry.
Rheological measurements to assess network properties under varying pH and ionic strength.
Drug loading and release studies using benzophenone as a model drug.

Main Results:

High complexation constants (approx. 10(4) L mol(-1)) indicate strong inclusion complex formation.
Rheological properties are sensitive to pH and ionic strength, suggesting multiple interaction mechanisms.
Slow drug release (10-12 days) was observed, with slower kinetics at pH 2 compared to pH 7.
Drug release at pH 7 is governed by both diffusion and host-guest interactions.

Conclusions:

The developed polymer networks exhibit robust associative interactions suitable for controlled drug delivery.
pH and ionic strength significantly modulate network behavior and drug release kinetics.
The system demonstrates potential for tunable drug release based on environmental conditions.