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Rotavirus gastroenteritis in uzbekistan: implications for vaccine policy in central Asia

Elmira T Flem1, Erkin Musabaev, Rivojiddin Juraev

  • 1Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway. elmira.flem@fhi.no

The Journal of Infectious Diseases
|October 13, 2009
PubMed

Insights

Rotavirus infections significantly impact children under 5 in Uzbekistan, causing many hospitalizations and deaths. Introducing rotavirus vaccines could be cost-effective for the national immunization program.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Public Health Surveillance

Background:

  • Rotavirus is a leading cause of severe gastroenteritis in young children globally.
  • Uzbekistan, with the largest birth cohort in Central Asia, is a key region for evaluating rotavirus vaccine impact.
  • The country's eligibility for international vaccine introduction funds necessitates understanding the disease burden.

Purpose of the Study:

  • To assess the burden of rotavirus disease in Uzbekistan among children under 5 years.
  • To determine the potential cost-effectiveness of rotavirus vaccine introduction in the national immunization program.

Main Methods:

  • Surveillance of rotavirus in stool samples from children under 5 with gastroenteritis (2005-2006).
  • Estimation of national rotavirus-associated mortality and hospitalization rates.
  • Genotyping of rotavirus strains.

Main Results:

  • Rotavirus was detected in 30% of 3537 children studied; 80% of infections occurred in children under 2.
  • The G1P[8] genotype was the most common strain identified in 2005.
  • Annual estimates suggest 1174-1857 deaths and 6394-6558 hospitalizations due to rotavirus in children under 5.

Conclusions:

  • Rotavirus accounts for a substantial proportion of gastroenteritis hospitalizations and deaths in young children in Uzbekistan.
  • Introducing rotavirus vaccines at subsidized prices may be a cost-effective public health intervention.
Abstract

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