Related Experiment Video

Updated: Jun 19, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Global mortality associated with rotavirus disease among children in 2004

Umesh D Parashar1, Anthony Burton, Claudio Lanata

  • 1Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. uap2@cdc.gov

The Journal of Infectious Diseases
|October 13, 2009
PubMed

Insights

Rotavirus infection causes over 500,000 deaths annually in children under 5, highlighting the need for effective rotavirus vaccines. Targeted vaccination strategies are crucial for reducing child mortality globally.

Area of Science:

  • Global Health
  • Infectious Diseases
  • Vaccinology

Background:

  • Estimating rotavirus disease burden is essential for assessing vaccine benefits and impact.
  • New rotavirus vaccines necessitate updated global and national mortality data.

Purpose of the Study:

  • To estimate global rotavirus-associated mortality in children under 5 years old.
  • To provide baseline data for monitoring rotavirus vaccine impact.

Main Methods:

  • Systematic review of 76 studies initiated after 1990 on rotavirus in hospitalized children.
  • Categorization of studies into 5 groups based on child mortality and geography.
  • Calculation of rotavirus-associated mortality by multiplying detection rates with diarrhea mortality data.

Main Results:

  • Rotavirus caused an estimated 527,000 deaths annually in children under 5, representing 29% of all diarrhea-related deaths.
  • India accounted for 23% of rotavirus deaths; 6 countries bore over half of the global burden.
  • Significant rotavirus mortality was observed in India, Nigeria, Congo, Ethiopia, China, and Pakistan.

Conclusions:

  • High rotavirus mortality necessitates targeted interventions, particularly vaccines.
  • Ensuring vaccine access in high-mortality countries is vital for maximizing impact.
  • Established baseline mortality figures will enable future assessments of vaccine effectiveness.
Abstract

More Related Videos

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Related Concept Videos

Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...