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Updated: Jun 19, 2026
12:21
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
Photosensitivity associated with selective serotonin reuptake inhibitors
V Doffoel-Hantz1, C Boulitrop-Morvan, A Sparsa
1Department of Dermatology, Hospital Dupuytren, Limoges, France.
Clinical and Experimental Dermatology
|October 13, 2009
Summary
Selective serotonin reuptake inhibitors (SSRIs) can cause rare photosensitivity reactions. This cross-reactivity suggests a link to methylation metabolism, requiring awareness for patients and clinicians before sun exposure or phototherapy.
Area of Science:
- Pharmacology
- Dermatology
- Toxicology
Background:
- Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressants.
- Photosensitivity is a potential adverse effect of various medications.
Observation:
- Three cases of photosensitivity reactions were observed.
- The reactions were linked to fluvoxamine and paroxetine, both SSRIs.
Findings:
- Photoallergic reactions suggest cross-reactivity between different SSRI molecules.
- Methylation metabolism may be a common mechanism underlying SSRI-induced photosensitization.
- While rare, SSRI photosensitivity necessitates clinical and patient awareness.
Implications:
- Clinicians and patients should be aware of the risk of photosensitivity with SSRIs.
- Discontinuation of SSRIs may be necessary before phototherapy or prolonged sun exposure.
- Further research into the mechanisms of SSRI photosensitivity is warranted.
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