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Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies

Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies

Published on: January 26, 2019

Cow's milk protein allergy: an entity for recognition in developing countries.

Ujjal Poddar¹, Surender Kumar Yachha, Narendra Krishnani

¹Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. ujjalpoddar@hotmail.com

Journal of Gastroenterology and Hepatology

|October 13, 2009

Summary

This summary is machine-generated.

Cow's milk protein allergy (CMPA) is a significant concern in India, often presenting with chronic diarrhea. Early diagnosis and dietary intervention are key to successful management and recovery in affected children.

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Area of Science:

Pediatric Gastroenterology
Allergy Immunology

Background:

Cow's milk protein allergy (CMPA) is a common condition in infants and children.
Accurate diagnosis and effective management are crucial for improving patient outcomes.

Purpose of the Study:

To identify cases of CMPA in a tertiary care hospital in India.
To analyze the clinical manifestations and treatment outcomes of CMPA.

Main Methods:

Prospective study evaluating children with chronic diarrhea.
Diagnostic tools included hemogram, serological tests, endoscopy, and intestinal biopsies.
Diagnosis confirmed by intestinal biopsy findings and milk challenge.

Main Results:

Forty CMPA cases were identified, primarily presenting with chronic diarrhea.
Sigmoidoscopy showed aphthous ulcers in 82%, and rectal biopsy was positive in 97%.
All patients improved on a milk-free diet, with successful reintroduction in 25 cases.

Conclusions:

CMPA is prevalent in India and requires clinical attention.
Aphthous ulcers and abnormal rectal biopsies suggest CMPA.
Timely milk challenges are essential for accurate diagnosis.