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Updated: Jun 19, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

Rapid access towards follow-up NOP receptor agonists using a knowledge based approach.

Ronald Palin1, John K Clark, Louise Evans

  • 1Department of Chemistry, Schering-Plough Research Institute, Newhouse, Lanarkshire ML15SH, UK. ronald.palin@spcorp.com

Bioorganic & Medicinal Chemistry Letters
|October 13, 2009
PubMed
Summary

Researchers identified novel NOP receptor agonists using a knowledge-based approach. Compound 51 shows high affinity and potency for the NOP receptor with decreased hERG channel affinity.

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