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Updated: Jun 19, 2026
FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Monozygotic multiple gestation after intracytoplasmic sperm injection and preimplantation genetic diagnosis
Ronit Haimov-Kochman1, Hagit Daum, Francine Lossos
1IVF Unit, Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. kochman@hadassah.org.il
Objective:
To report a possible association between intracytoplasmic sperm injection (ICSI)-preimplantation genetic diagnosis (PGD) and monozygotic multiple gestation.
Design:
Small case series.
Setting:
In vitro fertilization unit in an academic medical center.
Patient(S):
Three patients were treated with ICSI-PGD for sexing as well as selection against a known translocation.
Intervention(S):
Transfer of day 4 embryos to the uterus.
Main Outcome Measure(S):
Clinical pregnancy.
Result(S):
Two pairs of monozygotic twins and a triplet pregnancy.
Conclusion(S):
Repeated manipulation of the zona pellucida as well as extended embryo culture during ICSI-PGD treatments may result in monozygotic twin and triplet pregnancies.
