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Adenyl cyclase activity in human alveolar macrophages
F D Beusenberg1, J G van Amsterdam, J M van Schaik
1Department of Pharmacology, Erasmus University Rotterdam, The Netherlands.
Agents and Actions. Supplements
|January 1, 1990
Abstract:
The inflammatory mediators PGE2, DC-PGI2 and histamine as well as the beta-adrenergic drugs isoprenaline and salbutamol increase intracellular cyclic AMP-concentrations whereas Platelet Activating Factor does not induce any change in adenyl cyclase activity of normal human alveolar macrophages. Functional H2-histaminergic and beta 2-adrenergic receptor-subtypes are coupled to macrophage adenyl cyclase.