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Related Experiment Video

Updated: Jun 19, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Predicting recurrence of nonfunctioning pituitary adenomas.

Tae-Woong Noh¹, Hyeong Jae Jeong, Mi-Kyung Lee

¹Pituitary Tumor Clinic and Institute of Endocrinology, Yonsei Brain Research Institute, Yonsei University College of Medicine, 120-752 Seoul, Korea.

The Journal of Clinical Endocrinology and Metabolism

|October 13, 2009

Summary

Predicting nonfunctioning pituitary adenoma recurrence is possible using cellular markers. High levels of phospho-Akt and phospho-p44/42 MAPK, along with low phospho-CREB and ZAC1, indicate a higher risk of recurrence.

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

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Published on: January 17, 2018

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Nonfunctioning pituitary adenomas are often large at diagnosis, leading to surgery and potential recurrence.
Predicting recurrence post-surgery is crucial for determining the need for adjunctive therapies and reducing patient morbidity.

Purpose of the Study:

To identify cellular markers that can predict the recurrence of nonfunctioning pituitary adenomas after initial surgery.
To correlate specific cellular marker expression levels with the timing and likelihood of tumor recurrence.

Main Methods:

Utilized a tissue array block from 35 nonfunctioning pituitary adenoma cases, categorized by recurrence status (early, late, none).
Analyzed cellular markers associated with proliferation and apoptosis using immunohistochemical studies.

Main Results:

High Ki-67 and TUNEL labeling indexes correlated with tumor recurrence.
Elevated expression of phospho-Akt, phospho-p44/42 MAPK, and PTTG1 was linked to early recurrence.
Conversely, high expression of phospho-CREB and ZAC1 showed an inverse association with recurrence.

Conclusions:

Tumors exhibiting high phospho-Akt and phospho-p44/42 MAPK expression, and low phospho-CREB and ZAC1 expression, warrant close monitoring.
These marker profiles suggest a higher risk of recurrence, potentially necessitating adjunctive therapies.