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Liver abnormality in ovarian hyperstimulation syndrome.
N G Ryley1, R Forman, D Barlow
1Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Headington, Oxford, UK.
Human Reproduction (Oxford, England)
|November 1, 1990
Summary
Ovarian hyperstimulation syndrome (OHSS) can cause liver issues. This case highlights prolonged liver function abnormalities and specific ultrastructural changes in the liver following OHSS.
Area of Science:
- Reproductive Endocrinology
- Hepatology
- Pathology
Background:
- Ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovulation induction.
- Previous reports indicate potential liver involvement in OHSS, with one case showing ultrastructural liver biopsy abnormalities.
Observation:
- This report details a patient who developed severe OHSS 16 days post-ovulation induction.
- Liver function abnormalities, including elevated alkaline phosphatase and AST, were noted 11 days after OHSS onset and persisted for two months.
Findings:
- Liver biopsy revealed significant zonal fatty change (acinar zone 1) and inflammation.
- Electron microscopy identified mitochondrial crystalline inclusions and rough endoplasmic reticulum dilatation in the liver tissue.
Implications:
- This case highlights the potential for significant and prolonged liver involvement in severe OHSS.
- Understanding these ultrastructural changes may offer insights into the pathophysiology of OHSS-related liver injury.