Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

Imaging Studies III: Computed Tomography

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

Electron Microscope Tomography and Single-particle Reconstruction

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A fast all-optical 3D photoacoustic scanner for clinical vascular imaging.

Nature biomedical engineering·2024

Same author

Enhanced detection of threat materials by dark-field x-ray imaging combined with deep neural networks.

Nature communications·2022

Same author

Networks for Nonlinear Diffusion Problems in Imaging.

Journal of mathematical imaging and vision·2020

Same author

Novel time-resolved camera based on compressed sensing.

Optics express·2019

Same author

Fluorescence diffuse optical tomography using the split Bregman method.

Medical physics·2011

Same author

Accelerated boundary element method for diffuse optical imaging.

Optics letters·2011

Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026

Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026

Same journal

Corrigendum: Measured and Monte Carlo simulated electron backscatter to the monitor chamber for the varian TrueBeam linac (2016<i>Phys. Med. Biol</i>.<b>61</b>8779).

Physics in medicine and biology·2026

Same journal

Corrigendum: 3D range-modulator for scanned particle therapy: development, Monte Carlo simulations and experimental evaluation (2017<i>Phys. Med. Biol</i>.<b>62</b>7075).

Physics in medicine and biology·2026

Same journal

Recent progress in applications of computing to radiotherapy (ICCR 2016).

Physics in medicine and biology·2026

Same journal

Novel TMS coils designed using an inverse boundary element method.

Physics in medicine and biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

A combined reconstruction-classification method for diffuse optical tomography.

P Hiltunen¹, S J D Prince, S Arridge

¹Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Finland. petri.hiltunen@tkk.fi

Physics in Medicine and Biology

|October 13, 2009

Summary

This summary is machine-generated.

This study introduces a new algorithm for diffuse optical tomography (DOT) that combines classification and reconstruction. The method improves image contrast and spatial accuracy in DOT, offering better visualization for medical imaging applications.

More Related Videos

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging

Published on: June 2, 2009

Related Experiment Videos

Last Updated: Jun 19, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging

Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging

Published on: June 2, 2009

Area of Science:

Medical Imaging
Computational Science
Biophysics

Background:

Diffuse optical tomography (DOT) is a nonlinear, ill-posed inverse problem requiring regularization.
Accurate image reconstruction is crucial for interpreting DOT data.
Existing regularization methods may not fully leverage the underlying tissue properties.

Purpose of the Study:

To develop and validate a combined classification and reconstruction algorithm for DOT.
To enhance image contrast and spatial accuracy in DOT reconstructions.
To introduce a novel mixture of Gaussians prior for improved regularization.

Main Methods:

A novel algorithm integrating classification and reconstruction for DOT.
Utilizing a mixture of Gaussians prior to regularize the reconstruction process.
Employing an iterative approach combining Tikhonov regularization and expectation-maximization for parameter estimation.

Main Results:

The algorithm successfully enhances image contrast and spatial accuracy in DOT.
Simulated and phantom data demonstrate the effectiveness of the proposed method.
Probabilistic classifications showed a low rate of misclassified pixels.

Conclusions:

The combined classification and reconstruction algorithm offers significant improvements for DOT.
The mixture of Gaussians prior effectively regularizes DOT reconstructions.
This approach holds promise for advancing DOT-based imaging applications.