Diffuse laminar endocervical glandular hyperplasia: a case report.

Area of Science:

• Gynecologic Pathology
• Cervical Cancer Diagnosis
• Benign Endometrial Lesions

Background:

• Diffuse laminar endocervical glandular hyperplasia (DL EGH) is an exceptionally rare benign cervical lesion, with only 14 prior reported cases.
• DL EGH presents a diagnostic challenge due to its potential to mimic malignant endocervical adenocarcinoma.
• Accurate differentiation is crucial for appropriate patient management and avoiding overtreatment.

Observation:

• A 22-year-old woman presented with a significant exophytic cervical mass.
• Initial biopsies suggested adenocarcinoma, specifically minimal deviation adenocarcinoma.
• Imaging revealed no evidence of metastatic disease.

Findings:

• Surgical pathology definitively diagnosed the cervical mass as diffuse laminar endocervical glandular hyperplasia.
• The patient underwent successful radical abdominal hysterectomy with lymph node sampling.
• Histological examination confirmed the benign nature of the lesion, despite initial concerning biopsy results.

Implications:

• This case underscores the necessity of considering DL EGH in the differential diagnosis of cervical glandular lesions.
• Recognizing this rare entity can prevent misdiagnosis and unnecessary aggressive treatment for benign conditions.
• Further research into the pathogenesis and diagnostic markers for DL EGH may be warranted.