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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Related Experiment Video

Updated: Jun 19, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Increased response variability in autistic brains?

Mehmet Akif Coskun1, Larry Varghese, Stacy Reddoch

  • 1Department of Electrical and Computer Engineering, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Neuroreport
|October 13, 2009
PubMed
Summary
This summary is machine-generated.

This study investigated brain network noise in autism spectrum disorder (ASD). Results indicate that autistic individuals' brain responses to tactile stimulation are not noisier than those of typically developing individuals, challenging existing hypotheses.

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Area of Science:

  • Neuroscience
  • Autism Research
  • Brain Connectivity

Background:

  • A leading hypothesis suggests autistic brains have 'noisier' networks, implying reduced reliability in neural responses.
  • This 'noisy network' hypothesis predicts increased variability in evoked brain responses in individuals with autism spectrum disorder (ASD).

Purpose of the Study:

  • To investigate the 'noisy network' hypothesis by comparing neural response reliability in individuals with ASD and typically developing controls.
  • To examine differences in evoked responses to tactile stimulation between groups using magnetoencephalography (MEG).

Main Methods:

  • Magnetoencephalography (MEG) was used to record brain activity.
  • Participants included individuals with autism spectrum disorder (ASD) and matched typically developing controls.
  • Passive tactile stimulation was applied to the thumb and index finger of the dominant hand.

Main Results:

  • Multiple analyses did not reveal significantly higher response variability in the ASD group compared to controls.
  • No increased variability was observed for evoked responses to either thumb or index finger stimulation in individuals with ASD.

Conclusions:

  • The findings do not support the hypothesis that brain networks in autism are inherently noisier than in typical development.
  • This study provides evidence against the 'noisy network' theory as an explanation for atypical brain function in ASD.