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[Rasburicase for tophaceus gout treatment]
Ana Ribeiro1, Mónica Bogas, José Costa
1Interna Complementar de Reumatologia, Serviço Reumatologia, Unidade Local de Saúde do Alto Minho, Ponte de Lima. anaroxo79@iol.pt
Abstract:
The main obstacle to the treatment of hyperuricemia in patients with allergy to allopurinol is the limited availability of equally efficient alternative drugs. The authors present a clinical case of a patient with incapacitant tophaceus gout, allergy to allopurinol and contraindication for uricosurics, who was treated with rasburicase, an urato-oxidase recombinant, based on experience with this drug in tumoral lisis and in some cases reports of tophaceus gout. The authors also enhance the fact of being a patient with a sequelar hemiplegia of a previous cerebrovascular disease that presents tophus only in the not paretic member. The management of patients with allergy to allopurinol can be a clinical challenge, and the monthly rasburicase perfusions may be an alternative treatment of serious gout not treatable for other ways.
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