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[Thyroid dysfunction in children with chronic renal failure]

E Garrido-Magaña1, S E Heyser-Ortiz, A Aguilar-Kitsu

  • 1Servicio de Endocrinologia Pediátrica, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Institute Mexicano del Seguro Social, México DF, México.

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|October 13, 2009
PubMed

Insights

Thyroid dysfunction is common in children with chronic renal failure (CRF). Systematic screening for thyroid issues is crucial for improving care in pediatric CRF patients undergoing dialysis.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Chronic Kidney Disease Management

Context:

  • Children with chronic renal failure (CRF) often experience endocrine complications.
  • Thyroid dysfunction is a recognized comorbidity in pediatric CRF.
  • Dialysis modalities like peritoneal dialysis (PD) and hemodialysis (HD) may impact thyroid function.

Purpose:

  • To determine the frequency and types of thyroid dysfunction in pediatric CRF patients on PD or HD.
  • To assess the accuracy of goiter as an indicator of thyroid dysfunction in this population.
  • To evaluate the impact of thyroid dysfunction on growth and development.

Summary:

  • A cross-sectional study included 50 pediatric CRF patients (mean age 12 years) on PD or HD.
  • Thyroid dysfunction was identified in 28% of patients, including subclinical hypothyroidism, euthyroid sick syndrome, and primary hypothyroidism.
  • Goiter was present in 26% of patients, with 50% sensitivity and 83.3% specificity for detecting thyroid dysfunction.

Impact:

  • The high prevalence of thyroid dysfunction underscores the need for routine thyroid screening in children with CRF.
  • Early detection and management of thyroid dysfunction can potentially improve growth outcomes.
  • This study highlights the importance of integrated care for pediatric CRF patients.
Abstract

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