Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Renal Failure: Dose Adjustments

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Factors Affecting Renal Clearance: Renal Impairment

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Taladegib for the treatment of idiopathic pulmonary fibrosis (ENV-IPF-101): a multicentre, randomised, double-blind, placebo-controlled, phase 2a trial.

The Lancet. Respiratory medicine·2025

Same author

A pharmaco-economic analysis of second-line treatment with imatinib or sunitinib in patients with advanced gastrointestinal stromal tumours.

British journal of cancer·2008

Same author

Lipopopeptidephosphoglycan from Entamoeba histolytica activates human macrophages and dendritic cells and reaches their late endosomes.

Parasite immunology·2007

Same author

Amuchina 10% solution, safe antiseptic for preventing infections of exit-site of Tenckhoff catheters, in the pediatric population of a dialysis program.

Contributions to nephrology·2006

Same author

Triggering receptor expressed on myeloid cells (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients.

Clinical and experimental immunology·2006

Same author

Morphometric study of the human fetal heart. I. Arterial segment.

Clinical anatomy (New York, N.Y.)·2005

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

[Thyroid dysfunction in children with chronic renal failure].

E Garrido-Magaña¹, S E Heyser-Ortiz, A Aguilar-Kitsu

¹Servicio de Endocrinologia Pediátrica, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Institute Mexicano del Seguro Social, México DF, México.

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia

|October 13, 2009

Summary

Thyroid dysfunction is common in children with chronic renal failure (CRF). Systematic screening for thyroid issues is crucial for improving care in pediatric CRF patients undergoing dialysis.

Related Experiment Videos

Last Updated: Jun 19, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

Pediatric Nephrology
Endocrinology
Chronic Kidney Disease Management

Context:

Children with chronic renal failure (CRF) often experience endocrine complications.
Thyroid dysfunction is a recognized comorbidity in pediatric CRF.
Dialysis modalities like peritoneal dialysis (PD) and hemodialysis (HD) may impact thyroid function.

Purpose:

To determine the frequency and types of thyroid dysfunction in pediatric CRF patients on PD or HD.
To assess the accuracy of goiter as an indicator of thyroid dysfunction in this population.
To evaluate the impact of thyroid dysfunction on growth and development.

Summary:

A cross-sectional study included 50 pediatric CRF patients (mean age 12 years) on PD or HD.
Thyroid dysfunction was identified in 28% of patients, including subclinical hypothyroidism, euthyroid sick syndrome, and primary hypothyroidism.
Goiter was present in 26% of patients, with 50% sensitivity and 83.3% specificity for detecting thyroid dysfunction.

Impact:

The high prevalence of thyroid dysfunction underscores the need for routine thyroid screening in children with CRF.
Early detection and management of thyroid dysfunction can potentially improve growth outcomes.
This study highlights the importance of integrated care for pediatric CRF patients.