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Updated: Jun 19, 2026
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Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
Published on: September 11, 2013
[Late and recurrent serous choroidal detachment after trabeculectomy: case report]
Nikias Alves da Silva1, Felício Aristóteles da Silva
1Clínica de Olhos da Santa Casa de Misericórdia, Centro de Oftalmologia Avançada, Belo Horizonte, MG, Brazil. nikiasa@hotmail.com
Arquivos Brasileiros De Oftalmologia
|October 13, 2009
Summary
This case report details managing complex glaucoma. It highlights challenges with hypotensive agents causing serous choroidal detachment, ultimately resolved with repeat needling and 5-FU injections.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Surgical Complications
Background:
- An 85-year-old male presented with bilateral advanced primary open-angle glaucoma uncontrolled by maximal medical therapy.
- Co-existing conditions included senile cataract, asteroid hyalosis (OD), and age-related macular degeneration (OS).
Observation:
- Phacotrabeculectomy with mitomycin-C was performed OU but failed, necessitating reintroduction of hypotensive agents.
- Use of timolol/dorzolamide and brinzolamide led to serous choroidal detachment and hypotony in one or both eyes.
Findings:
- Discontinuation of the offending hypotensive agents resolved the choroidal detachment and normalized intraocular pressure (IOP).
- Repeat needling with subconjunctival 5-fluorouracil (5-FU) injections successfully managed the glaucoma.
Implications:
- This case underscores the potential for specific glaucoma medications to induce serous choroidal detachment.
- It demonstrates the efficacy of repeat needling and 5-FU injections as a salvage therapy for refractory glaucoma post-surgery.
