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Updated: Jun 19, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
The role of molecular genetic factors in age-related macular degeneration
Luciana Negrão Frota de Almeida1, Rachel Melilo Carolino, Diogo Cazelli Sperandio
1Hospital São Geraldo e Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Laboratório de Genética Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. luciananfalmeida@gmail.com
Abstract:
Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Although the etiology of AMD remains largely unknown, numerous studies have suggested that both genes and environmental risk factors significantly influence the risk of developing AMD. Recently, single nucleotide polymorphisms, DNA sequence variations found within the complement factor H (CFH) gene, have been found to be strongly associated with the development of AMD. Several other genes have had at least one positive association finding and deserve further exploration. The purpose of this review is to provide an extensive report of the current data of AMD genetics and the contribution of this knowledge helps to the better understanding of its pathophysiology.
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